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During the premarketing development of requip xl, patients with advanced parkinson s disease received requip xl or placebo as adjunctive therapy with l-dopa in a flexible-dose clinical trial.

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A double-blind, placebo-controlled, fixed-dose, parallel-group trial evaluated the dose-response of requip xl as adjunctive therapy to l-dopa in 352 randomized patients with advanced parkinson s disease hoehn yahr criteria stages ii-iv over a total dosing period of 18 weeks.