
236 grothe and colleagues 287 studied the pk of olanzapine in adolescents, observing a mean serum half-life of 37.
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In an analysis of 4 placebo controlled olanzapine monotherapy studies of adolescent patients ages 13 to 17 years , including those with schizophrenia 6 weeks or bipolar disorder manic or mixed episodes 3 weeks , olanzapine treated patients gained an average of 4.
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0 mg dl, serum sgot or sgpt less than or equal to three times the upper limit of normal, absolute neutrophil count 1500 mm 3 , negative urine pregnancy test in female patients of child bearing potential, no severe cognitive compromise, no known history of cns disease dementia, no treatment with another antipsychotic agent finasteride 1 mg without prescription. such as risperidone, quetiapine, clozapine, phenothiazine, or butyrophenone for 30 days prior to or during protocol therapy, no chronic administration of phenothiazine as an antipsychotic agent, no concurrent abdominal rt, no chronic alcoholism, no evidence of bowel obstruction, no known hypersensitivity to olanzapine, no known cardiac arrhythmia, congenital qt prolongation, uncontrolled ccf, or acute myocardial infarction within the previous six months, no history of uncontrolled diabetes mellitus vestibular dysfunction, no concurrent use of opiates quinolones, and normal serum electrolytes.
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Do not use epinephrine, dopamine, or other sympathomimetics with beta-agonist activity since the beta-stimulation may worsen hypotension in the setting of olanzapine overdose.
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