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Lincomycin was not found to be mutagenic in the Ames Salmonella reversion assay or the V79 Chinese hamster lung cells at the HGPRT locusIt did not induce DNA strand breaks in V79 Chinese hamster lung cells as measured by alkaline elution or chromosomal abnormalities in cultured human lymphocytesIn vivolincomycin was negative in both the rat and mouse micronucleus assays and it did not induce sex-linked recessive lethal mutations in the offspring of male DrosophilaHoweverlincomycin did cause unscheduled DNA syntheses in freshly isolated rat hepatocytes.
These are not all of the side effects that may occurIf you have questions about side effectscall your doctorCall your doctor for medical advice about side effects.
WARNINGBlack BoxRare but sometimes fatal intestinal problems have occurredpseudomembranous colitiswith use of lincomycinThereforeit should only be used to treat serious infections where less toxic antibiotics are not appropriateIt should not be used to treat nonbacterial infections such as upper respiratory infections.
Lincocin Sterile Solution contains benzyl alcohol as a preservativeBenzyl alcohol has been associated with a fatalGasping Syndromein premature infantsSee WARNINGSSafety and effectiveness in pediatric patients below the age of one month have not been establishedsee DOSAGE AND ADMINISTRATION
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