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Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatmentRead all directions and safety information for the nicotine productDo not smoke at any time if you are using a nicotine product along with ZybanToo much nicotine can cause serious side effects.

Bupropion appears to enhance monoaminergic neurotransmission via its effects on both the NE and DA transporterswith subsequent reuptake inhibition of these 2 neurotransmittersBupropion and 2 of its metaboliteshydroxybupropion and threohydrobupropionwere shown to decrease the uptake of NE and DA into rat and order nizagara online 33. mouse synaptosomes9 Bupropion’s activity as a DA transporter inhibitor is further supported by a recent study showing approximately a 3-fold increase in expression of the immediate early gene c-fos in human DA transporter cellsandif coincubated with DAan attenuation of the DA-induced c-fos in human DA transporter cells14 Acute administration of bupropion reduces firing of brain stem NE and DA neuronsdata on fileGlaxoSmithKlineResearch Triangle ParkN.CAdditionallyfiring rates of NE neurons in the locus ceruleus are inhibited after acute bupropion administration9 Microdialysis studies following acute administration of bupropion demonstrate that extra-cellular NE and DA concentrations are increased in the nucleus accumbensdata on fileGlaxoSmithKlineResearch Triangle ParkN.CFurther evidence of the NDRI action of bupropion was found when administration of NEor DA-blocking drugs was shown to reduce the efficacy of bupropionand hydroxybupropionin animal models of depression15.

Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatmentRead all directions and safety information for the nicotine productDo not smoke at any time if you are using a nicotine product along with ZybanToo much nicotine can cause serious side effects.

Weight gain would be an expected consequence of antidepressants with affinity for histamine and/or 5-HT 2C receptorsBupropion has no relevant affinity for these receptors and is not associated with weight gainIt is typically associated with a slight weight losse.gapproximately equal to 1.5 kg with initial treatmentIn the long-term relapse prevention studya greater weight loss was observed in patients with a greater body mass index at baseline71.

Drinking alcohol with bupropion may increase your risk of seizuresIf you drink alcohol regularlytalk with your doctor before changing the amount you drinkBupropion can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

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