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Serum chromogranin ACgAlevels increase secondary to drug-induced decreases in gastric acidityThe increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumorsHealthcare providers should temporarily stop esomeprazole treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are highIf serial tests are performede.gfor monitoringthe same commercial laboratory should be usedfor testingas reference ranges between tests may varysee CLINICAL PHARMACOLOGY

Acute interstitial nephritis has been observed in patients taking PPIs including NEXIUMAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue NEXIUM if acute interstitial nephritis developssee CONTRAINDICATIONS

Cutaneous lupus erythematosusCLEand systemic lupus erythematosusSLEhave been reported in patients taking PPIsincluding esomeprazoleThese events have occurred as both new onset and an exacerbation of existing autoimmune diseaseThe majority of PPI-induced lupus erythematosus cases were CLE.

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