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Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarsenessor swelling of the mouthfacelipstongueor throatSigns of infection like feverchillsvery bad sore throatear or sinus paincoughmore sputum or change in color of sputumpain with passing urinemouth soresor wound that will not healSigns of bleeding like throwing up blood or throw up that looks like coffee groundscoughing up bloodblood in the urineblackredor tarry stoolsbleeding from the gumsvaginal bleeding that is not normalbruises without a reason or that get biggeror any doxycycline 100mg canada. bleeding that is very bad or that you cannot stopSigns of liver problems like dark urinefeeling tirednot hungryupset stomach or stomach painlight-colored stoolsthrowing upor yellow skin or eyesSigns of a pancreas problempancreatitislike very bad stomach painvery bad back painor very bad upset stomach or throwing upChest pain or pressureVery upset stomach or throwing upFeeling very tired or weakVery bad dizziness or passing outLoose stoolsdiarrheaMuscle pain or weaknessNight sweatsA big weight lossFever that does not go awayChange in color or size of a moleA skin lump or growthA very bad brain problem called progressive multifocal leukoencephalopathyPMLhas happened with Imuranazathioprine tabletsIt may cause disability or can be deadlyTell your doctor right away if you have signs like confusionmemory problemslow mooddepressionchange in the way you actchange in strength on 1 side is greater than the othertrouble speaking or thinkingchange in balanceor change in eyesight.

Nausea and vomiting may occur within the first few months of therapy with IMURANand occurred in approximately 12of 676 rheumatoid arthritis patientsThe frequency of gastric disturbance often can be reduced by administration of the drug in divided doses and/or after mealsHoweverin some patientsnausea and vomiting may be severe and may be accompanied by symptoms such as diarrheafevermalaiseand myalgiassee PRECAUTIONSVomiting with abdominal pain may occur rarely with a hypersensitivity pancreatitisHepatotoxicity manifest by elevation of serum alkaline phosphatasebilirubinand/or serum transaminases is known to occur following azathioprine useprimarily in allograft recipientsHepatotoxicity has been uncommonless than 1in rheumatoid arthritis patientsHepatotoxicity following transplantation most often occurs within 6 months of transplantation and is generally reversible after interruption of IMURANA rarebut life-threatening hepatic veno-occlusive disease associated with chronic administration of azathioprine has been described in transplant patients and in one patient receiving IMURAN for panuveitis21,22,23 Periodic measurement of serum transaminasesalkaline phosphataseand bilirubin is indicated for early detection of hepatotoxicityIf hepatic veno-occlusive disease is clinically suspectedIMURAN should be permanently withdrawn.

Azathioprine and/or its metabolites have been found in low concentrations in foetal blood and amniotic fluid after maternal administration of azathioprine.

Patients receiving immunosuppressantsincluding IMURANare at increased risk of developing lymphoma and other malignanciesparticularly of the skinPhysicians should inform patients of the risk of malignancy with IMURANAs usual for patients with increased risk for skin cancerexposure to sunlight and ultraviolet light should be limited by wearing protective clothing and using a sunscreen with a high protection factor.

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