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Increased risk of deep vein thrombosis and pulmonary embolism have been reported with EVISTAsee WARNINGS AND PRECAUTIONSWomen with active or past history of venous thromboembolism should not take EVISTAsee CONTRAINDICATIONSIncreased risk of death due to stroke occurred in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary eventsConsider risk-benefit balance in women at risk for strokesee WARNINGS AND PRECAUTIONS and Clinical Studies
Reason for postingRaloxifene is used for the treatment and prevention of osteoporosisIt is a selective estrogen-receptor modulator with estrogen-agonist effects on bone and lipid metabolism but not the breasts and uterusThe drug’s effect on a woman’s risk of cardiovascular events and risk of invasive breast cancer was assessed in the RUTHRaloxifene Use for The HearttrialThe drug’s manufacturer recently disclosed that women taking the drug in the trial had an increased risk of death from stroke1.
EVISTA60 mg administered once dailyreduced the incidence of invasive breast cancer by 44compared with placeboabsolute risk reductionARR1.2 per 1000 women-yearsthis was primarily due to a 55reduction in estrogen receptorERpositive invasive breast cancer in the EVISTA group compared with placeboARR 1.2 per 1000 women-yearsThere was no reduction in ER-negative invasive breast cancerTable 8 presents efficacy and selected safety outcomes.
EVISTA should be discontinued at least 72 hours prior to and during prolonged immobilizatione.gpost-surgical recoveryprolonged bed restand patients should be advised to avoid prolonged restrictions of movement during travel because of the increased risk of venous thromboembolic eventssee WARNINGS AND PRECAUTIONS
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