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PharmacodynamicsThe capacity of labetalol HCl to block alpha receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold watercold-pressor testLabetalol HCl’s beta 1receptor blockade in man was demonstrated by a small decrease in the resting heart rateattenuation of tachycardia produced by isoproterenol or exerciseand by attenuation of the reflex tachycardia to the hypotension produced by amyl nitriteBeta 2receptor blockade was demonstrated by inhibition of the isoproterenol-induced fall in diastolic blood pressureBoth the alphaand beta-blocking actions of orally administered labetalol HCl contribute to a decrease in blood pressure in hypertensive patientsLabetalol HCl consistentlyin dose-related fashionblunted increases in exercise-induced blood pressure and heart rateand in their double productThe pulmonary circulation during exercise was not affected by labetalol HCl dosing.

This drug may make you dizzyAlcohol or marijuana can make you more dizzyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.

HOW TO USESee also Warning section.Take this medication by mouthusually twice a day or as directed by your doctorYou may take this medication with or without foodbut it is important to choose one way and take this medication the same way with every dose.Dosage is based on your medical condition and response to treatmentTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.Use this medication regularly to get the most benefit from itTo help you remembertake it at the same times each day.For the treatment of high blood pressureit may take several weeks before you get the full benefit of this drugIt is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick.Tell your doctor if your condition does not improve or if it worsensfor exampleyour blood pressure readings remain high or increase

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