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The pump system should not be implanted until the patient s response to bolus lioresal intrathecal injection is adequately evaluated.

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Ovarian cysts have been found by palpation in about 4of the multiple sclerosis patients that were treated with Lioresal for up to one yearIn most cases these cysts disappeared spontaneously while patients continued to receive the drugOvarian cysts are estimated to occur spontaneously in approximately 1to 5of the normal female population.

Check the labels on all your medicinessuch as allergy or cough-and-cold productsbecause they may contain ingredients that cause drowsinessAsk your pharmacist about using those products safely.

An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.

On each occasion that the dosing rate of the pump and/or the concentration of LIORESAL INTRATHECALbaclofen injectionin the reservoir is adjustedclose medical monitoring is required until it is certain that the patient’s response to the infusion is acceptable and reasonably stable.

All patients receiving trusted onlone pharmacy. intrathecal baclofen therapy are potentially at risk for withdrawalEarly symptoms of baclofen withdrawal may include return of baseline spasticitypruritushypotensionand paresthesiasPriapism may develop or recur if treatment with intrathecal baclofen is interruptedSome clinical characteristics of the advanced intrathecal baclofen withdrawal syndrome may resemble autonomic dysreflexiainfectionsepsismalignant hyperthermianeuroleptic-malignant syndromeor other conditions associated with a hypermetabolic state or widespread rhabdomyolysis.

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