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The effect of Hytrin on fertility was assessed in a standard fertility/reproductive performance study in which male and female rats were administered oral doses of 830 and 120 mg/kg/dayFour of 20 male rats given 30 mg/kg240 mg/M 220 times the maximum recommended human doseand five of 19 male rats given 120 mg/kg960 mg/M 280 times the maximum recommended human dosefailed to sire a litterTesticular weights and morphology were unaffected by treatmentVaginal smears at 30 and 120 mg/kg/dayhoweverappeared to contain less sperm than smears from control matings and good correlation was reported between sperm count and subsequent pregnancy.
2Shionoiri HGotoh EIto THata TIwatsubo HTakegawa KOgihara TMikami HIkegami HOtsuka AKatahira KKawaguchi YLong-term therapy with terazosin may improve glucose and lipid metabolism in hypertensivesa multicenter prospective studyAm J Med Sci 3071994s91-5.
If administration is discontinued for more than several daystherapy should be re-instituted using the initial dosing regimen.
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hytrin or terazosin is known to have a minor interaction with finasteride.
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