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Nauseavomitingloss of appetitestomach achediarrheaor darkening of the skin/nails may occurNausea and vomiting can be severeIn some casesdrug therapy may be necessary to prevent or relieve nausea and vomitingChanges in diet such as eating several small meals or limiting activity may help lessen some of these effectsIf these effects persist or worsennotify your doctor or pharmacist promptly.

Maximum concentration of cyclophosphamide is limited to 20 mg/mL because of solubility.

The following adverse reactions are discussed in more detail in other sections of the labeling.

The prescribing physician is solely responsible for making all decisions relating to appropriate patient care includingbut not limited todrugsregimensdosescheduleand any supportive care.

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