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The S-enantiomer of warfarin is mainly metabolized to 7-hydroxywarfarin by CYP2C9a polymorphic enzymeThe variant allelesCYP2C9*2 and CYP2C9*3result in decreased in vitro CYP2C9 enzymatic 7-hydroxylation of S-warfarinThe frequencies of these alleles in Caucasians are approximately 11and 7for CYP2C9*2 and CYP2C9*3respectively.

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